Orlistat and olestra can both lead to undigested lipids in the colon,yet they do so by contrasting mechanisms.Orlistat __________,whereas olestra __________.
A) inhibits pancreatic lipase; activates PPAR
B) inhibits pancreatic lipase; is a fat substitute that is not a substrate for pancreatic lipase
C) is a fat substitute that is not a substrate for pancreatic lipase; inhibits pancreatic lipase
D) activates PPAR ; inhibits pancreatic lipase

Question

Orlistat and olestra can both lead to undigested lipids in the colon,yet they do so by contrasting mechanisms.Orlistat __________,whereas olestra __________.
A) inhibits pancreatic lipase; activates PPAR 
B) inhibits pancreatic lipase; is a fat substitute that is not a substrate for pancreatic lipase 
C) is a fat substitute that is not a substrate for pancreatic lipase; inhibits pancreatic lipase 
D) activates PPAR ; inhibits pancreatic lipase

Quizplus · Accepted Answer

Orlistat inhibits pancreatic lipase, which is necessary for the breakdown and absorption of dietary fats in the intestines. Olestra, on the other hand, is a fat substitute that is not a substrate for pancreatic lipase. Because it cannot be broken down, it passes through the digestive system undigested and can lead to undigested lipids in the colon.

Orlistat and Olestra Can Both Lead to Undigested Lipids in the Colon,yet