Which Statement Is Not True About Enzymes

Which statement is not true about enzymes?

A) Enzymes orient substrates into positions that optimize chemical reactions between them.
B) An enzyme may cause physical strain in a substrate once the substrate has bound to the enzyme's active site.
C) Enzymes can use acid-base chemistry to destabilize bonds in substrates.
D) An enzyme can form a temporary covalent intermediate with a substrate as part of the catalytic mechanism.
E) Enzymes can shift the position of equilibrium to favor products.