Which Is an Example of an Enzyme Using Substrate Orientation

Which is an example of an enzyme using substrate orientation as a mechanism for lowering the activation energy of a reaction?

A) Aligning the substrate atoms so they are brought into proximity with each other, favoring the chemical reaction
B) Altering the hydrophobicity of a substrate (e.g., making a hydrophobic molecule hydrophilic)
C) Altering the shape of the enzyme to favor expulsion of the product
D) Aligning two different substrates such that their reactive atoms are held as far apart as possible
E) Chemically cleaving the substrate so that the small substrate fragments can enter solution more easily