The MLH1 protein dimerizes with the PMS2 protein to form a complex that is involved in the correction of errors of DNA replication.Loss-of-function mutations in the genes that encode for these proteins increase the incidence of colon cancer.Which type of DNA error would be repaired by the activity of this complex?
A) Mismatched bases
B) Chemically induced damage to nucleotides
C) Thymine dimers
D) Radiation-induced damage to nucleotides
E) All types of DNA errors

Question

Quizplus · Accepted Answer

The MLH1-PMS2 complex is involved in correcting errors of DNA replication, including the repair of mismatched bases. Loss-of-function mutations in the genes that encode for these proteins increase the incidence of colon cancer, indicating the importance of this complex in maintaining genomic stability. This complex is not involved in repairing chemically or radiation-induced damage to nucleotides or thymine dimers, suggesting that not all types of DNA errors are corrected by this complex.

The MLH1 Protein Dimerizes with the PMS2 Protein to Form