Which drug is the LEAST likely to cross the blood-brain barrier?

Name: Which drug is the LEAST likely to cross the blood-brain barrier?
Brand: Quizplus
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Question

Quizplus · Accepted Answer

Penicillin is a large hydrophilic molecule that cannot easily pass through the blood-brain barrier, which is a selective barrier that prevents many substances including larger molecules from entering the brain. Alcohol, barbiturates, and nicotine are all small enough and lipophilic enough to cross the blood-brain barrier easily.

Which Drug Is the LEAST Likely to Cross the Blood-Brain