What contributes to drug resistance to chemotherapeutic agents? (Select all that apply.)

Question

Quizplus · Accepted Answer

Drug resistance can occur by cellular production of a drug transport molecule,known as P-glycoprotein,that can transport the drug out of the cell; creation of selection pressure by favoring drug-resistant mutant cells; and reduction of target molecule sensitivity. Drug resistance does not occur by drug-induced mutation or increased drug uptake by tumor cells.

What Contributes to Drug Resistance to Chemotherapeutic Agents? (Select All