It is crucial that regulation occur at pyruvate dehydrogenase because:

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Pyruvate dehydrogenase is critical for regulating the flow of glucose into oxidative metabolism. Once pyruvate is converted to acetyl-CoA by pyruvate dehydrogenase, it is committed to oxidation in the citric acid cycle or fatty acid biosynthesis. This limits the amount of glucose that can be used for anaerobic energy production, such as with lactate dehydrogenase or pyruvate kinase. It also prevents alanine aminotransferase from using pyruvate for amino acid metabolism.

It Is Crucial That Regulation Occur at Pyruvate Dehydrogenase Because