Which of the following statements regarding enzymes and transition states is true?
A) stabilization of the transition state must be less than stabilization of ES for catalysis to occur
B) binding of substrate to an enzyme often causes strain, thus promoting transition state formation
C) the transition state conformation of an enzyme catalyzed reaction is identical to the conformation seen in the uncatalyzed transition state
D) formation of the transition state always assures that the reaction will proceed to product
E) none of the above are true

Question

Quizplus · Accepted Answer

Binding of substrate to an enzyme often causes strain, which helps to promote the formation of the transition state. This strain can come in the form of changes in bond angles or lengths, which can make it easier for the reaction to proceed. Choice A is incorrect because the stabilization of the transition state must actually be greater than the stabilization of ES for catalysis to occur. Choice C is incorrect because the transition state conformation is not necessarily identical in enzyme-catalyzed reactions compared to uncatalyzed reactions. Choice D is incorrect because the formation of the transition state does not guarantee that the reaction will proceed to product, although it does make it more likely.

Which of the Following Statements Regarding Enzymes and Transition States