Malonate inhibition of succinate dehydrogenase is an example of:
A) noncompetitive inhibition.
B) competitive inhibition.
C) mixed noncompetitive inhibition.
D) irreversible inhibition.
E) uncompetitive inhibition.

Question

Quizplus · Accepted Answer

Malonate competitively inhibits succinate dehydrogenase by binding at the active site, thereby preventing succinate from binding to the enzyme. Noncompetitive inhibition involves binding of the inhibitor to an allosteric site on the enzyme, while mixed noncompetitive inhibition involves binding of the inhibitor to both the allosteric and active sites. Irreversible inhibition involves covalent modification of the enzyme, while uncompetitive inhibition involves binding of the inhibitor to the enzyme-substrate complex.

Malonate Inhibition of Succinate Dehydrogenase Is an Example Of