What happens if misfolded proteins are generated in the ER at a faster rate than they can be exported to the cytoplasm?
A)They are degraded in the ER.
B)They are inserted into the ER membrane.
C)They are resynthesized in the ER.
D)They accumulate in the ER.
E)They accumulate in the Golgi complex.

Question

Quizplus · Accepted Answer

If misfolded proteins are generated in the ER at a faster rate than they can be exported to the cytoplasm, they will accumulate in the ER, leading to ER stress. This can then trigger the unfolded protein response (UPR), a cellular response mechanism that aims to restore ER homeostasis by reducing protein translation and increasing chaperone production. If the UPR is unable to restore ER homeostasis, the cell may undergo apoptosis.

What Happens If Misfolded Proteins Are Generated in the ER