Allogeneic immune responses lead to graft rejection.Which of the following best defines an allogeneic immune response in human-to-human transplantation?
A)An innate immune response mounted by an individual against transplanted cells or tissues derived from an unrelated individual.
B)An adaptive immune response mounted by an individual against transplanted cells or tissues derived only from an unrelated individual.
C)An adaptive immune response mounted by an individual against transplanted cells or tissues derived from a genetically non-identical individual.
D)An innate or adaptive immune response mounted by an individual against transplanted cells or tissues derived from a genetically non-identical individual.
E)An adaptive immune response mounted by an individual against transplanted cells or tissues derived from a genetically identical individual.

Question

Quizplus · Accepted Answer

Allogeneic immune responses are against molecules that are different between graft donor and graft recipient.Within species,molecular differences are largely due to genetic differences,i.e.polymorphisms of genes encoding the same molecules.Other than identical twins,all humans,including other family members,have many different versions,i.e.alleles,of genes encoding the same proteins.These differences are detected by the adaptive immune system in graft recipients,and stimulate allogeneic immune responses.The innate immune system does not recognize allogeneic differences.

Allogeneic Immune Responses Lead to Graft Rejection