Which of the following is a correct description of direct T cell recognition of allogeneic MHC molecules by graft recipients?
A)Recipient T cells recognize soluble donor MHC molecules shed from the graft cells.
B)Recipient T cells recognize peptides derived from allogeneic MHC molecules that are bound to the recipient's own MHC molecules on recipient antigen presenting cells.
C)Recipient T cells recognize intact allogeneic MHC molecules on graft cells,without the need to processing those MHC proteins into peptides and presenting them on self-MHC molecules.
D)Donor T cells in the graft recognize recipient peptides bound to recipient MHC molecules.
E)Recipient T cells act as antigen presenting cells to donor T cells.

Question

Quizplus · Accepted Answer

Many T cells in any individual can recognize and be activated by intact allogeneic MHC molecules,whether or not the peptides bound to the allogeneic MHC are polymorphic and different from self-peptides.This can be considered a cross-reaction of T cells that normally would recognize microbial peptides bound to self-MHC.The high frequency of T cell that can directly recognize allogeneic MHC is one reason why allogeneic T cell responses are so frequent and strong in graft recipients.Indirect allogeneic MHC recognition,described in choice B,also occurs in graft recipients.
Matching

Which of the Following Is a Correct Description of Direct