For each of the descriptions in questions ,choose the immunosuppressive or tolerance induction therapy for allograft rejection (A-I)that best matches it.
-Inhibits mTOR,and thereby inhibits IL-2 driven cell cycle progression in T cells
A)Azathioprine
B)Cyclosporine
C)Mycophenolate mofetil
D)Rapamycin
E)Anti-CD40L antibody
F)Anti-IL-2R antibody
G)CTLA4-Ig
H)OKT3
I)Corticosteroids

Question

Quizplus · Accepted Answer

Rapamycin is an antibiotic that binds to FK506 binding protein (FKBP)and inhibits T cell proliferation.The rapamycin-FKBP complex does this by binding another cellular protein,the mammalian target of rapamycin (MTOR),which has been observed to regulate cell cycle progression by modulating the expression of certain cyclins.Note that FK506,another immunosuppressive drug,also binds FKBP,and the complex binds and inhibits calcineurin,as does cyclosporine.

For Each of the Descriptions in Questions ,Choose the Immunosuppressive