Systemic Lupus Erythematosis (SLE) Is an Autoimmune Disease Characterized by the Development

Systemic lupus erythematosis (SLE) is an autoimmune disease characterized by the development of autoantibodies specific for DNA and other nuclear antigens. Patients with SLE show a wide variety of symptoms that include anemia, skin rashes, joint and muscle pain, heart problems, and kidney damage. This is considered a systemic autoimmune disease because:

A) Different patients have different symptoms.
B) All patients have damage to more than one organ.
C) The majority of patients have kidney damage.
D) The autoantigen targeted by the immune system is not-tissue specific.
E) Multiple different tissue-specific autoantigens are recognized in a single patient.