A disease resembling systemic lupus erythematosis (SLE) can be induced in mice. A key characteristic of this disease is the production of autoantibodies with specificity for double-stranded DNA (dsDNA), nucleosomes, and ribonucleotide-protein complexes (RNPs). When these mice are treated with a small molecule TLR7 and TLR9 inhibitor, twice a week starting at 4 months of age, the data in Figure Q4) are obtained. Figure Q4) In this system, the TLR7/TLR9 inhibitor:

Question

A disease resembling systemic lupus erythematosis (SLE) can be induced in mice. A key characteristic of this disease is the production of autoantibodies with specificity for double-stranded DNA (dsDNA), nucleosomes, and ribonucleotide-protein complexes (RNPs). When these mice are treated with a small molecule TLR7 and TLR9 inhibitor, twice a week starting at 4 months of age, the data in Figure Q4) are obtained.  Figure Q4) In this system, the TLR7/TLR9 inhibitor:

Quizplus · Accepted Answer

The production of autoantibodies with specificity for dsDNA, nucleosomes, and RNPs suggests that the B cells in these mice are activated by chromatin from apoptotic host cells. The TLR7/TLR9 inhibitor is likely preventing this activation by blocking the activation of TLR7 and TLR9, which are known to recognize nucleic acids. Thus, choice C is the best answer. Choices A, B, D, and E are not supported by the information provided.

A Disease Resembling Systemic Lupus Erythematosis (SLE) Can Be Induced