Treg cells that express FoxP3 are generally thought to have T-cell receptors that recognize self-peptides bound to MHC class II molecules. In the skin, keratin and filaggrin are among the self-antigens expressed. FoxP3+ Treg cells found in skin and skin-draining lymph nodes might be specific for the self-antigen, filaggrin. These FoxP3+ filaggrin-specific Treg cells:
A) Would inhibit the activation of naive filaggrin-specific and keratin-specific CD4 T cells
B) Would only inhibit the activation of naive filaggrin-specific CD4 T cells
C) Would inhibit the activation of all naive T cells in skin-draining lymph nodes following an infection
D) Would not inhibit naive T cells specific for antigens expressed by commensal microbes but not by host cells
E) Are the only subset of autoreactive cells expressing TGF- receptors
Correct Answer:
Verified
Q9: Multiple mechanisms provide a series of checkpoints
Q10: AIRE is a transcriptional regulator that promotes
Q11: All autoreactive CD4 T cells are not
Q12: Rheumatoid arthritis is often classified as
Q13: Nearly 80% of patients with autoimmune
Q15: A disease resembling systemic lupus erythematosis (SLE)
Q16: Due to its multiple roles in promoting
Q17: Some early studies aimed at deciphering
Q18: A subset of patients with imbalances in
Q19: Systemic lupus erythematosis (SLE) is an autoimmune
Unlock this Answer For Free Now!
View this answer and more for free by performing one of the following actions
Scan the QR code to install the App and get 2 free unlocks
Unlock quizzes for free by uploading documents