Mice lacking the poly Ig receptor (pIgR) have an immunodeficiency disease characterized by increased susceptibility to mucosal infections and an increase in the penetration of commensal microbes into the body's tissues. Yet, a genetic deficiency in the production of IgA antibodies is the most common form of human immunodeficiency, and is generally a mild disease and often even asymptomatic. This dichotomy can be explained by:
A) The difference in the immune system between mice and humans
B) The different types of commensal microbes found in mice and humans
C) The ability of pIgR to transport IgM across the gut epithelium
D) The reduced exposure of humans compared to mice to pathogens that infect via the gastrointestinal epithelium
E) The development of improved human hygiene, including pasteurization

Question

Quizplus · Accepted Answer

EThe ability of pIgR to transport IgM across the gut epithelium (C) helps compensate for the lack of IgA in humans, providing an alternative mucosal defense mechanism. Improved human hygiene, including pasteurization (E), reduces exposure to pathogens, mitigating the impact of IgA deficiency.

Mice Lacking the Poly Ig Receptor (PIgR) Have an Immunodeficiency