Vaccinia virus, used to immunize individuals against smallpox, has a long history of well-documented safe use in humans. Due to the eradication of smallpox, immunizations with vaccinia virus were halted, and babies born after 1970 no longer received this vaccine. This has led to the proposal to engineer vaccinia virus to express proteins derived from other human pathogens for which there are no current vaccines. For instance, the gene encoding the F protein of the respiratory syncytial virus (RSV) has been inserted into vaccinia virus (VaccV-F), and has been tested for its ability to induce anti-F protein antibody responses following immunization.strain if they were born before versus after 1970?
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