Some individuals with repetitive exposure to high doses of Schistosoma mansoni develop resistance to re-infection by this helminthic parasite. In contrast, other individuals remain highly susceptible. Population studies showed that resistant individuals had increased numbers of circulating eosinophils in their blood compared to susceptible individuals, and further, that these eosinophils had increased levels of:

Question

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Eosinophils play a crucial role in the immune response against parasitic infections, such as those caused by Schistosoma mansoni. The increased levels of the low affinity IgE receptor (FcεRII) on eosinophils in resistant individuals facilitate the binding to IgE antibodies that are specific to the parasite antigens, enhancing the eosinophil's ability to identify and destroy the parasite. This mechanism is part of the reason why these individuals exhibit resistance to re-infection.

Some Individuals with Repetitive Exposure to High Doses of Schistosoma γ\gammaγ

Some Individuals with Repetitive Exposure to High Doses of Schistosoma $\gamma$