Several effector T cell functions are mediated by cell surface molecules on the effector cell interacting with binding partners on the target cells. In the case of the CD40-CD40 ligand interaction, effector CD4 T cells express CD40 ligand, which binds to CD40 target cells. Individuals with a genetic deficiency in CD40 ligand expression show greatly reduced antibody responses, particularly to protein antigens which require CD4 TFH cell interactions with B cells. Another expected defect in these individuals would be:
A) Reduced recruitment of eosinophils by TH2 cells
B) Reduced recruitment of neutrophils by TH17 cells
C) Reduced production of anti-microbial peptides induced by TH17 cells
D) Reduced suppression of dendritic cells by Treg cells
E) Reduced activation of macrophages by TH1 cells
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