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If One Swapped the Regulatory Elements of the TCR α\alpha And TCR

Question 27

Essay

If one swapped the regulatory elements of the TCR α\alpha and TCR β\beta loci, so that rearrangement and expression of the TCR α\alpha locus occurred first, in double-negative thymocytes, and TCR β\beta rearrangement and expression were delayed until the double-positive stage, would T cell development proceed normally to generate mature T cells? Why or why not?

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No
The rearrangement and expression of t...

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