Proteins Found in the Circulation Travel Throughout the Body, Including

Proteins found in the circulation travel throughout the body, including the thymus. One example is serum albumin. Developing T cells with T-cell receptors specific for peptides of human serum albumin bound to MHC class II molecules would likely be:

A) Positively selected and would mature into CD4 T cells
B) Positively selected and would mature into CD8 T cells
C) Negatively selected in the thymus and deleted from the mature repertoire
D) Targeted for peripheral mechanisms of self-tolerance after emigrating from the thymus
E) Excluded from the T cell zones of the spleen after emigrating from the thymus