Small GTPases, such as Ras, Rho, and cdc42, are activated when they exchange their bound GDP for GTP. In the GTP-bound state, these proteins contribute to signaling by:

Question

Quizplus · Accepted Answer

When small GTPases such as Ras, Rho, and cdc42 are in their GTP-bound state, they can interact with target proteins and alter their activity, leading to downstream signaling events. This is a key way in which small GTPases contribute to cellular signaling. Option A is incorrect because hydrolysis of GTP to GDP would transition the small GTPases back to an inactive state. Option B is partially correct, as GAPs can interact with small GTPases, but they function to promote GTP hydrolysis, returning the small GTPases to their inactive state. Options D and E are unrelated to small GTPase signaling.

Small GTPases, Such as Ras, Rho, and Cdc42, Are Activated