The TCR Signaling Module Leading to Transcription Factor Activation Is $\gamma$

The TCR signaling module leading to transcription factor activation is dependent on the enzyme phospholipase-C- $\gamma$ (PLC- $\gamma$ ) . The mechanism by which PLC- $\gamma$ activates multiple transcription factors is by:

A) Generating two small second messengers that act on multiple target proteins in the T cell
B) Directly cleaving inhibitory subunits of multiple transcription factors, thereby releasing the active transcription factors
C) Generating two small second messengers that diffuse to the nucleus and activate transcription factors present there
D) Generating two small second messengers that act as chaperones to promote nuclear localization of transcription factors
E) Directly cleaving the lipid binding domain from membrane-tethered transcription factors, allowing them to migrate to the nucleus