A new strain of immunodeficient mice has been discovered, and found to have T cells that are unresponsive to TCR stimulation. The T cells from these mice have normal levels of the TCR complex on their surface, but when this TCR is stimulated, the cells fail to secrete IL-2. As a first step in determining the signaling defect responsible for this immunodeficiency, the T cells are stimulated with a phorbol ester (PMA) and Ionomycin. It is found that this treatment elicits IL-2 production by the immunodeficient T cells. Based on this information, candidate genes that could be mutated in these T cells include all of the following EXCEPT:
A) ZAP-70
B) PLC-
C) SLP-76
D) ITK
E) Calcineurin
Correct Answer:
Verified
Q1: Antigen receptors use multiple mechanisms to recruit
Q2: Antigen receptor signaling pathways are regulated by
Q4: Many receptors of the immune system activate
Q5: Antigen receptor signaling pathways are initiated
Q6: Immunoreceptor signaling proteins, such as the
Q7: Following TCR stimulation, the small GTPase Ras
Q8: The TCR signaling module leading to
Q9: Small GTPases, such as Ras, Rho, and
Q10: Several small GTPases play critical roles in
Q11: The TCR and BCR are multi-subunit receptor
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