The different classes of immunoglobulins differ in the sequences of their heavy chain constant regions. As a result, each class of antibody has distinct effector functions. Nonetheless, they are all found at about equal concentrations in the serum of healthy individuals.

Question

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The different classes of immunoglobulins (IgG, IgM, IgA, IgE, and IgD) do not exist at equal concentrations in the serum. IgG is the most abundant, followed by IgA, IgM, IgD, and IgE, which is present in the least amount.

The Different Classes of Immunoglobulins Differ in the Sequences of Their