The exon encoding the V region of an immunoglobulin protein is generated by a process of somatic recombination. This recombination event brings V gene and J gene segments together:

Question

Quizplus · Accepted Answer

Somatic recombination of V and J gene segments generates variability in the CDR3 sequence of the V region, which is critical for antigen recognition by immunoglobulins. The other choices are incorrect: A is incorrect because somatic recombination occurs only in B and T cells, not in all cells of the body; C is incorrect because alternative RNA splicing is not involved in the generation of V region sequences; D is incorrect because junctional diversity can be generated by nucleotide additions or deletions; and E is incorrect because the exon encoding the immunoglobulin protein is composed of multiple gene segments, not just the V and J segments.

The Exon Encoding the V Region of an Immunoglobulin Protein