Figure shows the germ-line configuration of three V gene segments (#1, 2, 3) , and two J gene segments (#4, 5) . Which of the choices below represents a DNA configuration that would result from V-to-J recombination?

Question

Quizplus · Accepted Answer

The V and J gene segments are brought together during VDJ recombination, and the intervening DNA is excised. The resulting DNA configuration has the V and J gene segment attached to one another, with the excised DNA fragment missing. In choice C, V segment 1 is spliced to J segment 5, resulting in a joined DNA sequence, with the intervening fragment removed.

Figure Shows the Germ-Line Configuration of Three V Gene Segments