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Some T Cells Express γ\gamma δ\delta T-Cell Receptors Rather Than α\alpha β\beta

Question 18

Multiple Choice

Some T cells express γ\gamma : δ\delta T-cell receptors rather than α\alpha : β\beta T-cell receptors. The organization of the α\alpha locus and the δ\delta locus helps to ensure that each T cell cannot express both types of T-cell receptors. The mechanism involved is that:


A) The rearrangement of a T-cell receptor α\alpha gene deletes the δ\delta locus on that allele.
B) The rearrangement of a T-cell receptor δ\delta gene deletes the α\alpha locus on that allele.
C) The RAG recombinase enzymes are down-regulated immediately after the first T-cell receptor genes rearrange.
D) The α\alpha : β\beta T-cell receptor signals the T cell to delete the δ\delta locus.
E) The γ\gamma : δ\delta T-cell receptor signals the T cell to delete the α\alpha locus.

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