Some pathogenic microorganisms encode proteins, such as the Staphylococcus Protein A, that bind to immunoglobulin constant region domains with high affinity. These microbial proteins provide a benefit to the microorganism by:

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Preventing antibodies bound to the microbe from binding to Fc receptors on phagocytes is a strategy used by some pathogens, like Staphylococcus aureus with its Protein A, to evade the immune system. By binding to the Fc region of antibodies, these microbial proteins prevent the antibodies from interacting with Fc receptors on immune cells like phagocytes, thereby inhibiting opsonization and phagocytosis.

Some Pathogenic Microorganisms Encode Proteins, Such as the Staphylococcus Protein