Several pathogens produce proteins, either membrane-bound or secreted, that inactivate C3b that might be deposited on the pathogen surface. C3b is specifically targeted due to its central position in all three complement pathways.

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C3b is a central component in all three complement pathways, and therefore many pathogenic microorganisms have developed mechanisms to inactivate or evade it, often by producing proteins that specifically target and inactivate C3b.

Several Pathogens Produce Proteins, Either Membrane-Bound or Secreted, That Inactivate