Question 1

Superoxide dismutase is an enzyme that converts the reactive superoxide ion to hydrogen peroxide in the body. Which metal is present in superoxide dismutase?
A)iron
B)calcium
C)magnesium
D)copper
E)cobalt

Accepted Answer

Copper is present in superoxide dismutase as a cofactor, which plays a crucial role in the enzyme's catalytic activity.

Question 2

How many stereoisomers are possible when platinum is bonded to 3 ammine ligands and 1 chloro ligand in a square planar complex?
A)1
B)2
C)3
D)4
E)5

Accepted Answer

The correct answer is A because the complex is square planar, which means that the ligands are arranged in a plane around the metal ion. The three ammine ligands are identical, so they cannot be distinguished from each other. The chloro ligand is different from the ammine ligands, so it can be distinguished from them. Therefore, there is only one possible stereoisomer.

Question 3

Iron-containing enzymes called ________ catalyze the metabolism of glucose to carbon dioxide and water.
A)anhydrases
B)cyctochromes
C)peroxidases
D)hydrogenase
E)nitrogenase

Accepted Answer

The iron-containing enzymes that catalyze the metabolism of glucose to carbon dioxide and water are called cytochromes.

Question 4

Iron accumulation in the human body has been implicated in some diseases. A chelating ligand sometimes is administered to treat these diseases. This treatment works because the ligand ________
A)oxidizes iron(II) to iron(III).
B)reduces iron(III) to iron(II).
C)precipitates the iron.
D)binds the iron to a protein.
E)forms a complex with the iron.

Accepted Answer

A chelating ligand works in treating diseases caused by iron accumulation by forming a complex with the iron. The complex is then easily eliminated from the body.

Question 5

Two isomers that are nonsuperimposable mirror images of each other are called ________
A)enantiomers.
B)structural isomers.
C)cis.
D)bidentate.
E)bis.

Accepted Answer

Nonsuperimposable mirror images are referred to as enantiomers.

Question 6

Carbonic anhydrase is a metalloenzyme of ________ that catalyzes the reaction between water and carbon dioxide to form bicarbonate ion.
A)iron
B)magnesium
C)copper
D)zinc
E)cobalt

Accepted Answer

Carbonic anhydrase is a metalloenzyme that contains a zinc ion in its active site. The zinc ion plays a crucial role in catalyzing the conversion of carbon dioxide and water to bicarbonate ion.

Question 7

What is the correct name for the following compound? 
A)trans-tetraamminedichlorochromium(II)
B)cis-tetraamminedichlorochromium(II)
C)cis-triamminedichlorochromium(II)
D)cis-tetraamminechlorochromium(II)
E)cis-tetraamminedichlorochromium(III)

Accepted Answer

The compound is a coordination complex consisting of a Chromium(II) ion coordinated with four Ammonia (NH3) ligands and two Chloride (Cl-) ligands. The ligands are arranged around the central Chromium(II) ion with a cis configuration, meaning they are located on the same side of the coordination sphere. Therefore, the correct name is cis-tetraamminedichlorochromium(II).

Question 8

Chlorophyll a is a pigment in plants that mediates conversion of carbon dioxide to carbohydrates using sunlight. Which metal ion is an important structural component of chlorophyll a? A)Na⁺ B)Mg²⁺ C)Ca²⁺ D)K⁺ E)Co²⁺

Accepted Answer

Magnesium (Mg) is an important structural component of chlorophyll a. This metal ion is essential for the absorption of light during photosynthesis, and it helps to stabilize the chlorophyll molecule. None of the other metal ions listed are known to be important components of chlorophyll a.

Question 9

Which of the following square planar complexes would have enantiomers? A)Pt(NH₃)₄²⁺ B)PtCl₄^2- C)Pt(NH₃)₂Cl₂ D)None have enantiomers. E)Pt(NH₃)₃Cl

Accepted Answer

Square planar complexes do not have enantiomers because they are planar and symmetric, lacking the chirality needed for enantiomerism.

Question 10

Which of the following molecules are enantiomers? 
A)I and II only
B)III and IV only
C)V and VI only
D)II and V only
E)I, II, V, and VI only

Accepted Answer

The answer of Which of the following molecules are enantiomers?...

Question 11

Cobalt is critical for function of which of the following? A)carbonic anhydrase B)coenzyme B₁₂ C)nitrogenase D)superoxide dismutase E)hemoglobin

Accepted Answer

Cobalt is a key component of vitamin B12 (cobalamin), which is a cofactor for certain enzymes, hence it is critical for the function of enzymes that require coenzyme B12.

Question 12

Molecules that have isomers that are nonsuperimposable mirror images are called ________
A)bis.
B)structural isomers.
C)cis.
D)bidentate.
E)chiral.

Accepted Answer

Molecules that have isomers that are nonsuperimposable mirror images are called chiral.

Question 13

Metal ions complexed with ________ are found in many important biological compounds.
A)a porphyrin ring
B)a benzene ring
C)cyanide ions
D)hydroxyl ions
E)potassium ions

Accepted Answer

Metal ions are often found complexed with porphyrin rings, which are a type of large, planar aromatic ring structure commonly found in important biological compounds such as heme, chlorophyll, and vitamin B12. The metal ion is typically located at the center of the porphyrin ring and can help to stabilize the aromatic structure, as well as participate in biological functions such as electron transport and catalysis.

Question 14

What is the correct name for the following compound? 
A)cis-diamminedichloroplatinum(II)
B)trans-diamminedichloroplatinum(III)
C)trans-diamminedichloroplatinum(II)
D)trans-dichlorodiammineplatinum(II)
E)cis-diamminedichloroplatinum(III)

Accepted Answer

The compound follows the naming convention for trans- and cis- isomers of square planar metal complexes, with the ligands arranged either in a cis or trans configuration. In this case, the ligands are diammine (two ammonia molecules) and dichloro (two chlorine atoms), and the metal is platinum. The roman numeral II indicates the oxidation state of the platinum ion. Cis-diamminedichloroplatinum(II) and trans-dichlorodiammineplatinum(II) are both technically correct names, but trans-diamminedichloroplatinum(II) is preferred because it follows the convention of naming the isomer with the ligands in a trans configuration first. The other choices are incorrect because they do not match the ligands, metal, or oxidation state of the compound.

Question 15

When iron complexes with the nitrogen atoms in a porphyrin ring, the unit is called a ________
A)myoglobin group.
B)porphyrate.
C)heme group.
D)ferrate group.
E)hemoglobin.

Accepted Answer

When iron complexes with the nitrogen atoms in a porphyrin ring, the resulting unit is called a heme group. Hemoglobin and myoglobin are proteins that contain a heme group. Porphyrate is not a commonly used term, and ferrate refers to a different oxidation state of iron.

Question 16

How many stereoisomers are there for the square planar compound Pt(NH₃)₂Cl₂, which is a potent anticancer agent? A)0 B)1 C)2 D)3 E)4

Accepted Answer

Square planar complexes, such as the one described for the Pt compound, can exhibit geometrical isomerism. However, due to the specific arrangement of ligands around the platinum center, this compound can exist as two distinct geometrical isomers: the cis and trans forms. These isomers arise from the different possible arrangements of the ligands (in this case, NHS, Cl, and two others) around the central metal atom. Optical isomerism is not possible in square planar complexes, limiting the total number of stereoisomers to 2.

Question 17

Anemia is associated with a deficiency of which element in the body?
A)iodine
B)aluminum
C)calcium
D)iron
E)potassium

Accepted Answer

Anemia is most commonly associated with a deficiency in iron, which is necessary for the production of hemoglobin in red blood cells.

Question 18

Cisplatin and other metallodrugs used with cancer are believed to function by ________
A)binding DNA and inhibiting cell replication.
B)disrupting ion flow across cancer cell membranes.
C)entering the cell mitochondria and halting energy production for cancer cells.
D)disturbing RNA production.
E)causing the cell nucleus to rupture.

Accepted Answer

Cisplatin and other metallodrugs bind to DNA in cancer cells and inhibit cell replication, leading to their cytotoxic effects on cancer cells.

Question 19

The effects of lead poisoning can sometimes be reversed by addition of a chelating agent to sequester the metal from the body. Which of the following compounds would be most effective to act as such a chelating agent? A)P(CH₃)₃ B)H₂O C)CN^- D)OH^- E)EDTA^4-

Accepted Answer

EDTA (ethylene-diamine-tetraacetic acid) is a commonly used chelating agent that can bind to metal ions, including lead, and remove them from the body. Its structure is given as EDTA-S2P2-. Option E is closest to EDTA in terms of its structure, and therefore, it would be the most effective as a chelating agent to sequester lead ions from the body.

Question 20

The metallodrug cisplatin is used to treat what type of disease?
A)diabetes
B)cancer
C)Alzheimer's
D)anemia
E)ALS (Lou Gehrig's disease)

Accepted Answer

Cisplatin is a chemotherapy drug used to treat various types of cancer, including ovarian, bladder, lung, and testicular cancer. It works by interfering with DNA replication and cell division, ultimately causing cancer cells to die.

Quiz 22: Transition Metals: Biological and Medical Applications

Superoxide dismutase is an enzyme that converts the reactive superoxide ion to hydrogen peroxide in the body. Which metal is present in superoxide dismutase?

How many stereoisomers are possible when platinum is bonded to 3 ammine ligands and 1 chloro ligand in a square planar complex?

Iron-containing enzymes called ________ catalyze the metabolism of glucose to carbon dioxide and water.

Iron accumulation in the human body has been implicated in some diseases. A chelating ligand sometimes is administered to treat these diseases. This treatment works because the ligand ________

Two isomers that are nonsuperimposable mirror images of each other are called ________

Carbonic anhydrase is a metalloenzyme of ________ that catalyzes the reaction between water and carbon dioxide to form bicarbonate ion.

What is the correct name for the following compound?

Chlorophyll a is a pigment in plants that mediates conversion of carbon dioxide to carbohydrates using sunlight. Which metal ion is an important structural component of chlorophyll a?

Which of the following square planar complexes would have enantiomers?

Which of the following molecules are enantiomers?

Cobalt is critical for function of which of the following?

Molecules that have isomers that are nonsuperimposable mirror images are called ________

Metal ions complexed with ________ are found in many important biological compounds.

What is the correct name for the following compound?

When iron complexes with the nitrogen atoms in a porphyrin ring, the unit is called a ________

How many stereoisomers are there for the square planar compound Pt(NH₃) ₂Cl₂, which is a potent anticancer agent?

Anemia is associated with a deficiency of which element in the body?

Cisplatin and other metallodrugs used with cancer are believed to function by ________

The effects of lead poisoning can sometimes be reversed by addition of a chelating agent to sequester the metal from the body. Which of the following compounds would be most effective to act as such a chelating agent?

The metallodrug cisplatin is used to treat what type of disease?

Quiz 22: Transition Metals: Biological and Medical Applications

Superoxide dismutase is an enzyme that converts the reactive superoxide ion to hydrogen peroxide in the body. Which metal is present in superoxide dismutase?

How many stereoisomers are possible when platinum is bonded to 3 ammine ligands and 1 chloro ligand in a square planar complex?

Iron-containing enzymes called ________ catalyze the metabolism of glucose to carbon dioxide and water.

Iron accumulation in the human body has been implicated in some diseases. A chelating ligand sometimes is administered to treat these diseases. This treatment works because the ligand ________

Two isomers that are nonsuperimposable mirror images of each other are called ________

Carbonic anhydrase is a metalloenzyme of ________ that catalyzes the reaction between water and carbon dioxide to form bicarbonate ion.

What is the correct name for the following compound?

Chlorophyll a is a pigment in plants that mediates conversion of carbon dioxide to carbohydrates using sunlight. Which metal ion is an important structural component of chlorophyll a?

Which of the following square planar complexes would have enantiomers?

Which of the following molecules are enantiomers?

Cobalt is critical for function of which of the following?

Molecules that have isomers that are nonsuperimposable mirror images are called ________

Metal ions complexed with ________ are found in many important biological compounds.

What is the correct name for the following compound?

When iron complexes with the nitrogen atoms in a porphyrin ring, the unit is called a ________

How many stereoisomers are there for the square planar compound Pt(NH3) 2Cl2, which is a potent anticancer agent?

Anemia is associated with a deficiency of which element in the body?

Cisplatin and other metallodrugs used with cancer are believed to function by ________

The effects of lead poisoning can sometimes be reversed by addition of a chelating agent to sequester the metal from the body. Which of the following compounds would be most effective to act as such a chelating agent?

The metallodrug cisplatin is used to treat what type of disease?

How many stereoisomers are there for the square planar compound Pt(NH₃) ₂Cl₂, which is a potent anticancer agent?