In ChIP-Seq, the DNA fragments to be sequenced are around 150 bp in length. What does this size of DNA represent?
A) The length of a promoter
B) The amount of DNA wrapped around a nucleosome
C) The average length of a gene
D) The average distance between genes
E) The amount of DNA between nucleosomes

Question

Quizplus · Accepted Answer

The size of DNA fragments in ChIP-Seq corresponds to the amount of DNA wrapped around a nucleosome, which is approximately 147 bp long. ChIP-Seq is typically used to identify DNA sequences associated with specific proteins, such as transcription factors or histone modifications, that are bound to chromatin. By breaking the chromatin into fragments and sequencing the DNA fragments, researchers can determine where these proteins are binding in the genome.

In ChIP-Seq, the DNA Fragments to Be Sequenced Are Around