Which of the following might complicate the interpretation of ChIP-Seq data?
A) Because histones can be moved around or ejected from the chromatin, DNA that is only sometimes wrapped around a histone might not be sequenced.
B) DNA wrapped around nucleosomes can never be sequenced.
C) The regions of DNA wrapped around a histone is too long to be sequenced with current technologies.
D) The DNA between nucleosomes are too compacted to be sequenced.

Question

Quizplus · Accepted Answer

ChIP-Seq data can be complicated by the fact that histones can be moved around or ejected from the chromatin, leading to DNA that may only sometimes be wrapped around a histone and may not be sequenced. The other choices are not accurate.

Which of the Following Might Complicate the Interpretation of ChIP-Seq