What Is the Possible Sequence of Events Leading to Cancer

What is the possible sequence of events leading to cancer development?

A) Loss of heterozygosity of an oncogene, benign tumor growth, malignant tumor growth
B) Benign tumor growth, loss of heterozygosity of an oncogene, malignant tumor growth
C) Loss of heterozygosity of a tumor suppressor, benign tumor growth, malignant tumor growth
D) Loss of heterozygosity that converts oncogene into tumor suppressor, benign tumor growth, malignant tumor growth
E) All of these scenarios are plausible.