If a developing fetus made beta hemoglobin subunits instead of gamma hemoglobin subunits, what would be MOST likely to occur? A) The fetus would extract O₂ from its mother's blood more effectively. B) The fetal hemoglobin would have a higher affinity for 2,3-bisphosphoglycerate. C) The fetal hemoglobin would have a lower affinity for CO. D) The fetus would not be able to extract O₂ from its mother's blood as effectively. E) The fetus would be less susceptible to sickle cell anemia.

Question

Quizplus · Accepted Answer

Fetal hemoglobin (HbF) has a higher affinity for oxygen compared to adult hemoglobin (HbA) due to its gamma subunits, which allow the fetus to extract oxygen more effectively from the mother's blood. Beta hemoglobin subunits, typical of adult hemoglobin, would reduce this efficiency, making it harder for the fetus to extract oxygen.

If a Developing Fetus Made Beta Hemoglobin Subunits Instead of Gamma