An alternative repair system by error-prone translesion DNA synthesis can result in a high mutation rate because:

Question

Quizplus · Accepted Answer

The error-prone translesion DNA synthesis involves DNA polymerases that lack exonuclease proofreading activities, which means they cannot correct mistakes once they have been made. This increases the likelihood of mutations occurring during replication. Choice A is incorrect because the modified nucleotides may not necessarily be incorporated more readily by the error-prone DNA polymerases. Choice B is incorrect because RecA and SSB proteins are involved in DNA repair and recombination, but do not necessarily hinder replication accuracy. Choice C is incorrect because replication occurring much faster than normal has not been suggested to be a factor in the high mutation rate associated with error-prone translesion DNA synthesis. Choice D is incorrect because DNA polymerase III is not involved in error-prone translesion DNA synthesis.

An Alternative Repair System by Error-Prone Translesion DNA Synthesis Can