Which Statement Does NOT Describe a Feature of Site-Specific Recombination

Which statement does NOT describe a feature of site-specific recombination?

A) A specific recombinase enzyme is required.
B) The energy of the phosphodiester bond is preserved in covalent enzyme-DNA linkage.
C) Recombination sites have non-palindromic sequences.
D) Formation of Holliday intermediates is required.
E) Insertions or deletions can result from site-specific recombination.