Which of the following is the most specific laboratory test to diagnose chronic myelogenous leukemia?

Question

Quizplus · Accepted Answer

Leukocyte alkaline phosphatase (LAP) is a specific laboratory test that can help diagnose chronic myelogenous leukemia (CML). In CML, LAP activity is reduced or absent in neutrophils, which distinguishes it from other leukemias where LAP activity is normal or increased. Increased bone marrow fibrosis and reticulin fibers, increased eosinophils and basophils, and blasts in the bone marrow are non-specific findings that can be seen in other types of leukemias or myeloproliferative disorders.

Which of the Following Is the Most Specific Laboratory Test