Which of the following tests can confirm a paroxysmal nocturnal hemoglobinuria diagnosis in a patient?

Question

Quizplus · Accepted Answer

Flow cytometry for cell surface markers is considered the gold standard for diagnosing paroxysmal nocturnal hemoglobinuria (PNH) because it can detect the absence of certain glycosylphosphatidylinositol (GPI)-anchored proteins on the surface of red blood cells, white blood cells, and platelets, which is characteristic of PNH. The Sucrose hemolysis test (sugar water test), the Reticulocyte count, and the Ham test (acidified serum lysis test) can be supportive of a PNH diagnosis but are not sufficient for confirmation.

Which of the Following Tests Can Confirm a Paroxysmal Nocturnal