Which one of the following interactions is NOT a stabilizing force at the tertiary level of protein organization?
A)an ionic bond between a positively charged R group and a negatively charged R group
B)hydrophobic clustering of nonpolar R groups in the interior of a protein
C)hydrogen bonding between the carbonyl oxygen of one peptide bond and an amide hydrogen of a nearby peptide bond
D)disulfide linkages between cysteine residues
E)van der Waals interactions between R groups in close proximity

Question

Quizplus · Accepted Answer

Hydrogen bonding between the carbonyl oxygen of one peptide bond and an amide hydrogen of a nearby peptide bond is not a stabilizing force at the tertiary level of protein organization. It is a stabilizing force at the secondary level of protein organization, where it forms alpha-helices and beta-sheets. At the tertiary level, stabilizing forces include hydrophobic interactions, ionic bonds, disulfide linkages, and van der Waals interactions.

Which One of the Following Interactions Is NOT a Stabilizing