What could be one way to solve the problem of tandem repeats complicating the alignment of DNA fragments in shotgun sequencing?

Question

Quizplus · Accepted Answer

Sequencing longer DNA fragments would help to avoid the presence of tandem repeats in the DNA fragments that need to be aligned, as longer fragments are less likely to contain repeated sequences. This would simplify the alignment process and improve the accuracy of the sequencing results. Options B and C would not directly address the issue of tandem repeats complicating alignment. Option D may help to resolve the sequence of the tandem repeats themselves, but would not necessarily solve the problem of aligning the DNA fragments that contain the repeats.

What Could Be One Way to Solve the Problem of Tandem