Which One of Following Statements Explains Why Genome Annotation Is

Which one of following statements explains why genome annotation is an ongoing, dynamic process in need of continued updating?

A) Our understanding of genes and gene function changes.
B) The functions and interactions of macromolecules are never the same.
C) Sequences change daily because mutation rates are extremely high.
D) Certain structures like hairpins are not predictable using older annotation techniques.
E) All of these choices are correct.