What is one cellular/molecular basis for dopamine action on VTA leading to addiction? A) Increases the AMPA/NMDA receptor ratio on VTA dopamine neurons B) Increases the Ca²⁺ current on VTA neurons C) Closes potassium channels and therefore enhances conduction velocity in VTA neurons D) Decreases the GABA receptor current on VTA neurons

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Quizplus · Accepted Answer

Dopamine action on VTA increases the AMPA/NMDA receptor ratio. This leads to an increase in glutamatergic transmission, which can lead to excitatory plasticity changes on VTA dopamine neurons. These changes contribute to the development of addiction.

What Is One Cellular/molecular Basis for Dopamine Action on VTA