Activation of type 1 mGluRs induces LTD through protein translation. What do you predict would happen to LTD if you could selectively increase PP2A phosphatase that regulates FMRP phosphorylation?
A) mGluR activation would result in FMRP phosphorylation and repression of protein translation. This would enhance LTD.
B) mGluR activation would result in FMRP dephosphorylation and repression of protein translation. This would decrease LTD.
C) mGluR activation would result in an increase in phosphorylated FMRP which would increase repression of protein translation. This would decrease LTD.
D) mGluR activation would result in an increase in dephosphorylated FMRP which would decrease repression of protein synthesis. This would enhance LTD.

Question

Quizplus · Accepted Answer

This is similar to the proposed model for the Fmr1 knockout mice. These mice express enhanced hippocampal LTDwith type 1 mGluR activation. The hypothesis is that activation of mGluR results in removal of postsynaptic AMPARs which requires protein translation. Phosphorylated FMRP normally represses protein translation so the lack of the FMRP gene increases protein translation and enhances LTD. PP2Aphosphatase dephosphorylates FMRP which would increase protein translation and enhance LTD.

Activation of Type 1 MGluRs Induces LTD Through Protein Translation