In Figure , if you were to conditionally restore MeCP2 protein to a MeCP2 knockout mouse at week 10, through removing a lox-stop allele with an inducible excision, how do you predict that would change the percent surviving animals? Justify your answer. Figure Q11-39
A) It would increase at week 10.
B) It would remain the same at week 10.
C) It would continue to decrease but at a slower rate.
D) It would decrease even faster.

Question

In Figure , if you were to conditionally restore MeCP2 protein to a MeCP2 knockout mouse at week 10, through removing a lox-stop allele with an inducible excision, how do you predict that would change the percent surviving animals? Justify your answer.  Figure Q11-39
A) It would increase at week 10. 
B) It would remain the same at week 10. 
C) It would continue to decrease but at a slower rate. 
D) It would decrease even faster.

Quizplus · Accepted Answer

The increase in the number of deaths would be stopped after conditional restoration of CeCP2 so that there were be the same number of surviving animals after week 10. MeCP2 is continuously required in adulthood. This suggests that restoring MeCP2 expression will prevent Rett symptoms and prevent early deaths.

In Figure , If You Were to Conditionally Restore MeCP2