The loss of Numb in the Drosophila SOP lineage results in two IIa precursors and the production of extra hair and socket cells at the expense of neuron and sheath cells, while the overexpression of Numb results in extra neuron and sheath cells at the expense of hair and socket cells. Which cell type(s) does Notch activity specify?
A) IIa precursor
B) Socket cell
C) Neuron
D) Both a and b
E) Both a and c

Question

Quizplus · Accepted Answer

Numb inhibits Notch activity, so loss of Numb results in excessive Notch activity and gain of Numb reduces Notch activity. We can deduce that Notch specifies the fates seen in the absence of Numb-that is, the IIa precursor and the socket cells.

The Loss of Numb in the Drosophila SOP Lineage Results