Which of the following are sufficient for synapse formation and maturation in cultured retinal ganglion cells?
A) Astrocytes
B) Thrombospondins
C) Thrombospondins and glypicans
D) a and c
E) None of the above

Question

Quizplus · Accepted Answer

Astrocytes and conditioned media from cultured astrocytes dramatically increases postsynaptic currents as a result of increased synapse number and enhanced synaptic strength. Only the first effect could be mimicked by the addition of TSP alone, but adding both thrombospondins and glypicans also enhanced synaptic strength.

Which of the Following Are Sufficient for Synapse Formation and Maturation