Various concentrations of Shh along the dorsoventral axis serve to activate or repress several transcription factors which then act in combination to specify neural progenitor domains and, ultimately, neurons (Figure Q7-5). The spinal cord progenitor domain in which Pax6 and Nkx6.1, but not Irx3 or Nkx2.2, are expressed will give rise to: Figure Q7-5
A) V3 interneurons.
B) V2 interneurons.
C) V1 interneurons.
D) V0 interneurons.
E) motor neurons.

Question

Various concentrations of Shh along the dorsoventral axis serve to activate or repress several transcription factors which then act in combination to specify neural progenitor domains and, ultimately, neurons (Figure Q7-5). The spinal cord progenitor domain in which Pax6 and Nkx6.1, but not Irx3 or Nkx2.2, are expressed will give rise to:  Figure Q7-5
A) V3 interneurons. 
B) V2 interneurons. 
C) V1 interneurons. 
D) V0 interneurons. 
E) motor neurons.

Quizplus · Accepted Answer

This combination of transcription factors corresponds to the pMN domain, which gives rise to motor neurons.

Various Concentrations of Shh Along the Dorsoventral Axis Serve to Activate