There are three Robo genes (Robo, Robo2, and Robo3) encoding receptors for Slit, which acts as a midline repellant. In homozygous Slit mutant embryos, all axons collapse at the midline, while in homozygous Robo mutant embryos, axons re-cross the midline, resulting in thinner longitudinal tracts and thicker commissures (Figure Q7-8). Figure Q7-8
What would you expect the ventral nerve cord phenotype of a triple Robo mutant (loss of function of all three Robo genes) to be? Briefly explain your reasoning.

Question

There are three Robo genes (Robo, Robo2, and Robo3) encoding receptors for Slit, which acts as a midline repellant. In homozygous Slit mutant embryos, all axons collapse at the midline, while in homozygous Robo mutant embryos, axons re-cross the midline, resulting in thinner longitudinal tracts and thicker commissures (Figure Q7-8).  Figure Q7-8
What would you expect the ventral nerve cord phenotype of a triple Robo mutant (loss of function of all three Robo genes) to be? Briefly explain your reasoning.

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The Answer of There are three Robo genes (Robo, Robo2, and Robo3) encoding receptors for Slit, which acts as a midline repellant. In homozygous Slit mutant embryos, all axons collapse at the midline, while in homozygous Robo mutant embryos, axons re-cross the midline, resulting in thinner longitudinal tracts and thicker commissures (Figure Q7-8).  Figure Q7-8
What would you expect the ventral nerve cord phenotype of a triple Robo mutant (loss of function of all three Robo genes) to be? Briefly explain your reasoning.

There Are Three Robo Genes (Robo, Robo2, and Robo3) Encoding